A silent mutation with unknown mechanism of C1311T in exon 11 combined with IVS11 T93C (G6PD 1311/93) has been reported in G6PD deficient individuals in many populations. In our previous study, G6PD 1311/93 was identified as the common G6PD variant in one of the Malaysian aboriginal groups. Here, we report the screening for this variant via PCR-RFLP method and then direct sequencing of the entire 3´UTR of the G6PD gene in 175 aboriginal volunteers and 45 non-aboriginals. In the aboriginal...
Serum samples will be collected from 100 individuals who are suffering from Duodenal Ulcer and other gastric disorders. Presence of H. pylori will be determined by culture and histological examination of gastric biopsy specimens. Patients who undergo gastrectomy and hence diagnosed with DU can be enrolled for sampling. For the non-ulcerous group, subjects from health clinics who receive a gastrointestinal endoscopic examination and showed no lesions of DU will be used. This serves as the...
Put yourself into the body of someone who is need of a vital organ. You are on a waiting list, but who knows when you will receive this precious organ. The doctor says the chances of receiving an organ donor are slim because of your rare genetic make-up. The thought of praying for another human to die, just so you can live, seems selfish, but today, the only way to receive an organ is from the death, or the chance of death, of another human being. Even then, the donor may not match.  Now...
Somatic cells can be reprogrammed to a embryonic like state by the induction of four transcription factors: Sox2, Oct4, KLf4 and c-myc. The produced cells are called "induced pluripotent stem cells" The process of inducing pluripotency in somatic cells can be divided into two stages. In the first stage lineage associated genes are repressed and the epigenome of the target cells was reset to an ES cell like ground state. Also an open chromatin state, to allow the transcription of ES...
Drug abuse is nowadays a more and more urgency youth problem all over the world. As an international commercial city, Hong Kong is exposed to this social problem as well, which bring enormous social and economic cost to individuals, families, communities and the whole society there. It is really an issue which requires the public to pay much attention to. In this paper, the author introduced the contemporary situation of teenager psychoactive drug abuse in Hong Kong (including these young...
Blood pressure is measured as the pressure of the blood in the radial artery when the heart is contracting (systolic pressure) over the pressure of the blood when the heart is relaxing (diastolic pressure). Having high blood pressure can lead to potentially fatal health issues such as cardiovascular disease so it is important to maintain a healthy blood pressure. In 2001 Vasan et al. studied 6859 subjects with normal to high blood pressure who had no previous record of cardiovascular disease....
Stem Cell Research is believed by many to be the future of medical treatments, as stem cells have the unique ability to regenerate and differentiate into a variety of different cell types. Bone marrow and umbilical cord blood stem cells are already being used to treat leukaemia and cardiovascular disease. This is just the start of the potential benefits that could arise from stem cell research. In the future the use of embryonic stem cells, induced pluripotent stem cells (iPSCs), and...
Organometallic chemistry is the chemistry of compounds which contain a metal carbon bond. Research interest in this area is largely fueled by potential applications of organometallic compounds as catalysts in industrial chemistry. A catalyst is defined as a substance that accelerates the rate of achieving chemical equilibrium, and which can be recovered unchanged at the end of a reaction. Catalytic processes can be broadly defined into two categories: 1) homogeneous catalysis, a process where...
Topamax, also known as topiramate, is an anti-epileptic drug with broad-spectrum activity and has Food and Drug Administration (FDA) indication approval for monotherapy epilepsy, adjunctive therapy epilepsy in children and adults, and prophylactic treatment of migraines in adults.1 The proposed mechanisms of action are that it may block voltage-sensitive Na+ channels, enhance GABA-A receptors, inhibit the effect of glutamate receptors, and weakly inhibit isozyme II and isozyme IV. 1 Clinical...
Platelets are irregularly-shaped, colourless bodies that are present in blood. They have sticky surfaces which facilitate the blood clotting process thrombosis and act to maintain homeostasis. Platelets run relatively near the endothelial lining of the blood vessel wall and contact the lumenal surface offering a observation of the endothelial surface for lesions and abnormalities. They are then provoked by either pathological or physiological experiences to stimulate and start thrombosis. In...